This project aims 1) (i) to characterize the abnormalities of the UNGE and its microenvironment (metabolites derived from PUFAs, digestive microbiota) in medullary and cauda equina pathologies, (ii) to identify if these abnormalities are associated with clinical disorders and (iii) to identify new therapeutic targets in order to improve the management of the patients In parallel and in mirror of the digestive disorders, it aims 2) to characterize the remodeling of the urothelium and its microenvironment (lipid mediators and urinary microbiota) associated with the vesico-sphincter disorders observed in patients with spinal cord disease, in particular detrusor overactivity, in order to identify new therapeutic targets or biomarkers of response to treatment (in particular drug treatment and intra-detrusor botulinum toxin).