"The Enteric Nervous System in gut and brain disorders"
Characterization of EGC-T cells interactions and role in disease recurrence
Graphical abstract
Project display
The enteric nervous system (ENS), composed of neurons and enteric glial cells (EGCs), plays an essential role in the homeostasis of the gastrointestinal system. Neurons are known for their role in the transmission of information, but EGCs also have a very important role in intercellular communication.
Recent studies indicate that good communication between GECs and cells of the immune system would be crucial to maintain homeostasis within the digestive wall. Neuro-immune interactions would be critical in chronic inflammatory bowel diseases (IBD) such as Crohn's disease.
Therefore, it is important to understand the mechanisms and consequences of LT/ EGC interactions. In particular, we are studying:
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the impact of LT adhesion to EGCs on glial and lymphocyte phenotypes
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the impact of adhesion molecules on the formation of plexi
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the use of plexites as markers of postoperative recurrence in patients with Crohn's disease.
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Left, Interactions between T cells and enteric glial cells in vitro (Video obtained by holotomography). Right, myenteric (GMy) and submucosal (GSM) lymph nodes (micrograph obtained by full field optical coherence tomography).
Researchers / Clinicians
Philippe Naveilhan
+33 2 40 41 29 74
philippe.naveilhan@univ-nantes.fr
Arnaud Bourreille
+33 2 40 08 31 52
arnaud.bourreille@chu-nantes.fr
Isabelle Neveu
+33 2 40 41 29 74
isabelle.neveu@univ-nantes.fr
Guillaume Meurette
+33 2 40 08 31 52
guillaume.meurette@univ-nantes.fr
ITA
Tony Durand
+33 2 40 41 29 50
tony.durand@univ-nantes.fr
Students
Catherine Le Berre
+33 2 40 41 11 07
catherine.leberre@univ-nantes.fr
Collaborators
Kulmira Nurgali, Melbourne, Australie
Michalina Gora, Geneva, Switzerland
Publications
Pabois J , Durand T, Le Berre C, Filippone RT, Noël T, Durieu E, Bossard C, Bruneau S, Rolli-Derkinderen M, Nurgali K, Neunlist M , Bourreille A, Neveu I, Naveilhan P. Role of ICAM-1 in the Adhesion of T Cells to Enteric Glia: Perspectives in the Formation of Plexitis in Crohn's Disease. Cell Mol Gastroenterol Hepatol. 2024 Feb 29:S2352-345X(24)00050-X. doi: 10.1016/j.jcmgh.2024.02.016. Link
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Le Berre C, Naveilhan P, Rolli-Derkinderen M. Enteric glia at center stage of inflammatory bowel disease. Neurosci Lett. 2023 Jul 13;809:137315. doi: 10.1016/j.neulet.2023.137315. Epub 2023 May 29. Link
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Durand T, Paul-Gilloteaux P, Gora M, Laboudie L, Coron E, Neveu I, Neunlist M, Naveilhan P. Visualizing enteric nervous system activity through dye-free dynamic full-field optical coherence tomography. Commun Biol. 2023 Mar 2;6(1):236. Link
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Pabois, J., Durand, T., Le Berre, C., Gonzales, J., Neunlist, M., Bourreille, A., Naveilhan, P., Neveu, I., 2020. T cells show preferential adhesion to enteric neural cells in culture and are close to neural cells in the myenteric ganglia of Crohn’s patients. Journal of Neuroimmunology 577422. Link
Belarif, L.*, Danger, R.*, Kermarrec, L.*, Nerrière-Daguin, V., Pengam, S., Durand, T., Mary, C., Kerdreux, E., Gauttier, V., Kucik, A., Thepenier, V., Martin, J.C., Chang, C., Rahman, A., Guen, N.S.-L., Braudeau, C., Abidi, A., David, G., Malard, F., Takoudju, C., Martinet, B., Gérard, N., Neveu, I., Neunlist, M., Coron, E., MacDonald, T.T., Desreumaux, P., Mai, H.-L., Le Bas-Bernardet, S., Mosnier, J.-F., Merad, M., Josien, R., Brouard, S., Soulillou, J.-P., Blancho, G., Bourreille, A., Naveilhan, P.*, Vanhove, B.*, Poirier, N.*, 2019. IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease. J. Clin. Invest. 130. Link
Kermarrec, L., Durand, T., Gonzales, J., Pabois, J., Hulin, P., Neunlist, M., Neveu, I., Naveilhan, P., 2018. Rat enteric glial cells express novel isoforms of Interleukine-7 regulated during inflammation. Neurogastroenterol. Motil. e13467. Link
Pochard, C., Coquenlorge, S., Freyssinet, M., Naveilhan, P., Bourreille, A., Neunlist, M., Rolli-Derkinderen, M., 2018. The multiple faces of inflammatory enteric glial cells: is Crohn’s disease a gliopathy? Am. J. Physiol. Gastrointest. Liver Physiol. Link
Kermarrec, L., Durand, T., Neunlist, M., Naveilhan, P., Neveu, I., 2016. Enteric glial cells have specific immunosuppressive properties. J. Neuroimmunol. 295–296, 79–83. Link